von Willebrand Disease (vWD) is one of the most common congenital bleeding disorders, affecting ~1%* of the world’s population. An accurate diagnosis can be very challenging due to the heterogeneity of the disorder and preanalytical variables that may affect the assays used in the diagnosis. Clinical laboratories may perform both screening and complex assays to measure different properties and activities of von Willebrand factor (vWF) to aid clinicians with diagnosis. However, these assays may be adversely affected by preanalytical variables and often have altered performance characteristics that may contribute to inadequate interpretation.
- Define vWD and its history
- Go over current classification of vWD and assays utilized
- Review structure and function of vWF
- Discuss methods/technologies for diagnosing vWD, assay limitations, and preanalytical variables influencing vWD testing and interpretation
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