Hematology analyzers count and characterize blood cells for the screening and monitoring of disease. Analyzers vary in capabilities, sophistication and detection technologies. The most common technologies are electrical impedance, radio frequency conductivity, optical light scatter (optical flow cytometry), cytochemistry and fluorescence. Optimal combinations of these detection methods provide an accurate automated complete blood count (CBC) including white blood cell (WBC) differential in a short turnaround time.
Although many other detection methods are still in use, optical technology has represented a key innovation in automated hematology analysis since its introduction. Light, scattered and detected at specific angles, captures an array of information about cell size, structure, inner complexity, nuclear segmentation and cytoplasmic granulation. As an innovative expansion of optical flow cytometry, Multi-Angle Polarized Scatter Separation (MAPSS™) technology (Abbott Diagnostics, Hematology, Santa Clara, CA, USA) uses four different light scatter signals to characterize distinct cellular features for the identification of various blood cells. MAPSS™ technology reliably automates WBC differentials, and continues to be improved and expanded upon. The MAPSS™ and advanced MAPSS™ technology that are integrated in Abbott hematology analyzers enable clinical laboratories to obtain high quality results.
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